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Sufferers enduring an overdose may possibly current with hypokalemia, hypochloremia, and hyponatremia. Take care of patients with symptomatic and supportive remedy like fluids and electrolytes. Vasopressors can be administered to deal with hypotension and oxygen could possibly be supplied for respiratory impairment.
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Irbesartan is a specific competitive antagonist of AT1 receptors by using a A great deal higher affinity (more than 8500-fold) to the AT1 receptor than to the AT2 receptor, and no agonist exercise.
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The renin-aldosterone connection is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist tends to reverse the potassium decline related to these diuretics.